Hubei Humanwell Pharmaceutical Excipients Co.,ltd.
  Home About us Products Quality News R&D Contact us Jobs 中文版  
                  Main products
 
 
 
    Products
 

Gelatin Empty capsule

Gelatin empty capsule is the cap and body by the combined two piece of hard quality and flexibility of the space capsule.The capsule should be smooth, uniform color, smooth incision,no deformation and strange smell. The product has three kind of type transparent, translucent, opaque. There are various size of capsule,the company can produces different specifications O #, 1 #, 2 #, 3 #etc. Capsule color is various, modulated of their desired color according to customer requirements. The capsule also can color printing, showing a unique custom appearance.

Characteristics and advantages

The capsules can be very effective cover up to drugs the unpleasant taste and odor, slender shape of capsules. easy to swallow, the most popular consumer formulations.

Pullulan polysaccharide empty capsule

The natural of pullulan polysaccharide empty capsule is different from traditional animal source capsule, it is from starch or sugar as raw material, produced by microorganism fermentation extracellular natural polymer polysaccharide products. has wide applicability, no gelatin crosslinking reaction of amino acid in the risk (crosslinking easily after cause disintegration or dissolve out lower), drug release speed is relatively stable, the advantages of smaller individual differences.

 

Hydroxypropyl methyl cellulose (hpmc) empty capsule

Hydroxypropyl methyl cellulose empty capsule as a new plant capsule, with greater dissolution, high humidity tolerance, low steam through quantity etc, and with its unique sources, mature technology and variaus technical advantage, for preparation industry provides a larger development space.

 

Vegetable empty capsule features:

> Low moisture content , HPMC capsules cantains 60% less moisture than gelatin capsule.
> Resilient and non brittle at low moisture content. it is perfect for hydroscopic materials.
> Excellent stability.
> Easy to go further coating with GRAS or traditional formula.
> Environment friendly and health conscious.

ICATION OF GELATIN EMPTY CAPSULE

Size 00 0 1 2 3 4
weight mg 118 96 76 61 48 38
Tolerance mg +7 +6 ? ? ? ?
capacity Capsule volume ml 0.95 0.68 0.50 0.37 0.30 0.21


Powder denisity/
Capsule capacity mg

0.6g/ml 546 408 300 222 180 126
0.8g/ml 728 544 400 296 240 168
1g/ml 910 680 500 370 300 210
1.2g/ml 1092 816 600 444 360 252
Length of the capsule parts (body and cap)
Body inches 0.796
0.726 0.654 0.601 0.535 0.480
Tolerance inches ?.018 ?.018 ?.018 ?.018 ?.018 ?.018
Body mm 20.22 18.44 16.61 15.27 13.59 12.19
Tolerance mm ?.46 ?.46 ?.46 ?.46 ?.46 ?.46
cap Capinches 0.462
0.422 0.385 0.352 0.318 0.284
Tolerance inches ?.018
?.018 ?.018 ?.018 ?.018 ?.018
Cap mm 11.74 10.72 9.78 8.94 8.08 7.21
Tolerance mm ?.46 ?.46 ?.46 ?.46 ?.46 ?.46
External diameter Body inches 0.322 0.289 0.261 0.239 0.219 0.199
Body mm 8.18 7.34 6.63 6.07 5.57 5.05
Cap inches 0.336 0.300 0.272 0.250 0.229 0.209
Tolerance mm 8.53 7.64 6.91 6.35 5.82 5.32
Overall closed length Inches 0.917 0.854 0.765 0.709 0.626 0.536
Tolerance inches ?.012 ?.012 ?.012 ?.012 ?.012 ?.012
mm 23.3 21.7 19.4 18.0 15.9 14.3
Tolerance mm ?.3
?.3 ?.3 ?.3 ?.3 ?.3


PHYSIOCHEMICAL STANDARDS OF GELATIN EMPTY CAPSULE

Item Require
ldentification Positively reaction
Degree of tightness ≤1/10
Brittle ≤5/50
Disintegration ≤10min
Heavy metals ≤40ppm
Sulfita ≤O.01%
C2H5CIlO In line with the provisions
Loss on drying 12.5% - 17.5%
ASH Transparent ≤2.0%
Translucent ≤3.0%
Opaque ≤5.0%
Viscosity
≥60mm2/s
Chrominm ≤2ppm
Ethylene Oxide ≤0.0001%
Metyl Parabe ≤0.05%
MICROBIAL Bacteria ≤lOOO piece/g
Mildew ≤lOO piece/g
Escherichia coli NEG
Salmonella NEG

FUNDAMENTAL REQUIREMENT OF FILLING ROOM

To keep thermometer and hygrometer qualified
> The instruments should be kept in good working conditions
> To be examined and maintained regula rly
> To be put in a suitable place for away from the air outlet of air conditioner
> To be calibrated to their qualification at regular intervals by concerning measuring department

The recommended filling room environment
Temperature:20癈 to 24癈 Relative humidity: 45 %-55 %

Environmental Control
> The filling room should be conformed to the GMP requirement
> To note down the temperature and humidity twice a shift
> Air conditioner . dehumidizer and humidifier are ready for use
> The filling room operation procedure should be observed

Miscellaneous
> To avoid heat generation source radiation
> Filling room to be well insulated from outside
> To use curtains if sunlight shines directly into the room through windows

Storage and using of capsules:

> Capsules should be stored in the room with the temperature between l01: t0 251: and the relative humidity of 35%-65%.
> Capsule cartons should be kept away from walls and a certain distance from the floor to avoid moisture.
> Tighten up tha plastic bags with capsules inside
> Avoid direct sunshine, keep away from heat generation and water sources.
> Capsule cartons should be stored in the place where there is the similar condition with filling room at least half-day before they can be open for filling, in case there are big differences of the temperature and humidity between warehouse and filling room.
> Scoop out and put down capsules gently to prevent defects of mashes, loose pieces and Snap-Fit closed etc. Caused by the improper handling of the capsules.
> No capsules can be used for those touched by bare hands.


 
Copyright(C)2010,Hubei Humanwell Pharmaceutical Excipients Co.,ltd. All Rights Reserved.  Supported by ChinaPharmNet Toocle     后台管理
分分11选五投注技巧 广东快乐十分在线投注 江苏11选五专家推荐号码 青海省11选五开奖 浙江十一选五开奖结果201五 北京赛车app下载安装 证券配资 世界四大赌城收入排名 徐州股票配资公司 湖北福彩官方网站 中原内配资本原罪 298棋牌游戏下载 比较好的股票配资公司 南国七星彩票特区论坛 股票推荐软件可以叫炒股软件么 体彩排列五走势图 最靠谱的投资理财